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Epithalon: Research Overview
Epithalon (also referred to as Epitalon, AEDG) is a synthetic tetrapeptide corresponding to a fragment of the pineal gland protein epithalamin, studied primarily in relation to telomerase activity and cellular aging models.
A 2025 review published in the International Journal of Molecular Sciences examined Epitalon across in vitro cell and tissue models, animal models including Drosophila melanogaster, mice, rats, and rhesus monkeys, human clinical trials, and in silico physicochemical studies, summarizing reported properties across these varied model systems (PMC).
A related in vitro study examined the effects of Epitalon on telomere length, hTERT mRNA expression, telomerase activity, and alternative lengthening of telomeres (ALT) in human breast cancer, fibroblast, and epithelial cell lines using 2D cell-culture models; the peptide was associated with increased telomere length and hTERT expression in the cancer and normal cell lines examined, with telomerase activity increases observed in the normal cells (PMC).
For laboratory research use only — not for human consumption. This content is presented for educational and informational purposes and is not intended as medical advice, a treatment claim, or usage instruction.
